EZH2 and diffuse large B-cell lymphoma: Each of these cell lines are known to be derived from GCB-type DLBCL, and each of their mutational profiles further suggests that they are of the EZB subtype, as defined by Wright et al. [4] and characterized by mutations in genes such as EZH2, CREBBP, and KMT2D. STAT6 mutations are typically associated with the EZB subtype, and our patient data further asserts that STAT6 mutant rrDLBCL is of the EZB subtype (Fig. S1).