NFKB1 and cancer: It has been reported that FLOT2 participates in the development of several types of malignant tumors, which activates the PI3K/AKT/mTOR, PI3K/AKT/MAPK pathways and NF-κB signaling to promote cell proliferation, migration and invasion (Asp et al. 2014; Gong et al. 2013).