Considering the long survival of patients with EGFR mutated NSCLC who received sequential first/second generation followed by the third‐generation TKIs due to the development of T790M, along with increasing use of large next generation sequencing (NGS) panels and WES as routine molecular workup at least in the larger academic institutions in the foreseeable future [31], this study analyzed the feasibility of EGFR p.T790M prediction using deep genetic profiling of baseline tissue samples. Here, EGFR is linked to non-small cell lung carcinoma.