The results in Figure 7D, 7E showed that significantly higher positive rates of IL-1β (p < 0.001) and IL-18 (p = 0.002) were seen in the puncture-induced rat model, implying the activation of inflammation in LDD model group, however, Sesamin treatment significantly lowered the protein levels of IL-1β (p = 0.012) and IL-18 (p = 0.012). The gene discussed is IL18; the disease is Lhermitte-Duclos disease.