In our studies of FLT3-ITD–expressing cell lines and AML patient blasts, Pim inhibitors alone did not downregulate c-Myc, but Pim and FLT3 inhibitor cotreatment downregulated c-Myc more markedly and more rapidly than FLT3 inhibitor alone, likely contributing to enhanced apoptosis induction by combination therapy, demonstrated previously (9–12) and here. This evidence concerns the gene FLT3 and acute myeloid leukemia.