Cotreatment decreased GSK-3β (S9) phosphorylation in Ba/F3-ITD cells and FLT3-ITD AML blasts, and the decrease in GSK-3β (S9) phosphorylation preceded c-Myc and Mcl-1 downregulation (Fig. 7A and B). The gene discussed is GSK3B; the disease is acute myeloid leukemia.