We previously showed that concurrent Pim and FLT3 inhibition increases apoptosis induction in cells with FLT3-ITD, but not wild-type FLT3, through posttranslational downregulation of the antiapoptotic protein Mcl-1 (12), which is also upregulated in AML with FLT3-ITD (8). This evidence concerns the gene PIM1 and acute myeloid leukemia.