PIM1 and acute myeloid leukemia: In our studies of FLT3-ITD–expressing cell lines and AML patient blasts, Pim inhibitors alone did not downregulate c-Myc, but Pim and FLT3 inhibitor cotreatment downregulated c-Myc more markedly and more rapidly than FLT3 inhibitor alone, likely contributing to enhanced apoptosis induction by combination therapy, demonstrated previously (9–12) and here.