We previously showed that concurrent Pim and FLT3 inhibition increases apoptosis induction in cells with FLT3-ITD, but not wild-type FLT3, through posttranslational downregulation of the antiapoptotic protein Mcl-1 (12), which is also upregulated in AML with FLT3-ITD (8). Here, MCL1 is linked to acute myeloid leukemia.