As one of the pathways involved in triglyceride synthesis, abnormal expression of de novo lipogenesis-related factors such as sterol-regulatory element binding proteins (SREBP-1c), ATP citrate lyase (ACLY), acetyl coenzyme A carboxylase 1 (ACC1), and fatty acid synthase (FASN) and dysfunction in lipid metabolic pathways cause lipid deposition and contribute to the development of NAFLD [6]. The gene discussed is SREBF1; the disease is metabolic dysfunction-associated steatotic liver disease.