Comparison of the transcriptomic profiles of three myeloma cell lines between those treated with HDACi by broad or isoform-selective inhibitor and those left untreated identified Myc as one of the aberrantly deregulated genes, which is known to be a hallmark in the majority of human cancers: it regulates cell proliferation, differentiation, and apoptosis via regulation of a number of target genes and is involved in tumorigenesis (38, 48, 49). Here, MYC is linked to plasma cell myeloma.