A role in epilepsy for Kv7.5 has been suggested by an early immunohistochemistry study in brain slices that showed a downregulation of Kv7.5 in hippocampal neurons from epileptic patients (47); more recently, mutations in Kv7.5 have been found in patients with intellectual disability, and epileptic encephalopathy showing clinical features that are quite different from those due to mutations in Kv7.2 and Kv7.3 (18, 48). This evidence concerns the gene KCNQ2 and Epileptic encephalopathy.