IL6 and breast carcinoma: Although ΙL-1B is primarily produced from immune cells, it can be synthesized and secreted from several types of solid tumors (Jin et al., 1997; Wu et al., 2016), where it stimulates the expression of IL-6 and COX-2, which are promoting factor for breast cancer aggressiveness (Reed et al., 2009; Oh et al., 2016).