The reduced clonogenic growth of MDA-MB-231 herein may be attributed to the upregulation of some tumor suppressor proteins such as TSPAN6, MAPK6, SPRY2, HAUS4, stomatin (STOM) and conserved oligomeric golgi complex subunit 8 (COG8) (Table 1). The gene discussed is TSPAN6; the disease is neoplasm.