PMID:25644331; programmed cell death 6-interacting protein (PDCD6IP) and Rabenosyn-5 (ZFYVE20) are potential urinary biomarkers for upper gastrointestinal cancer (Sarosiek et al., 2016), PMID:23777424; a functional insertion–deletion polymorphism in the promoter of PDCD6IP is associated with the susceptibility of hepatocellular carcinoma in a Chinese population and PMID:22369209; PDCD6 is an independent predictor of progression-free survival in epithelial ovarian cancer (Figure 2). This evidence concerns the gene RBSN and hepatocellular carcinoma.