In summary, our analysis and experimental corroboration support the hypothesis that three competing endogenous RNA networks, namely, OIP5-AS1/hsa-miR-204-5p/BIRC5, DCP1A/hsa-miR-204-5p/BIRC5, and PPP1R9B/hsa-miR-204-5p/BIRC5, represent potential therapeutic intervention points for HCC. Here, PPP1R9B is linked to hepatocellular carcinoma.