In the analysis of immune cell infiltration in gliomas, we found that M2 macrophages outnumbered M1 macrophages in the tumor microenvironment of gliomas in high-risk group, and the three ferroptosis-related risk genes, AURKA, HSPB1, and NNMT, significantly inhibited ferroptosis of glioblastoma cells and promoted the polarization of M1 macrophages to M2. Here, AURKA is linked to central nervous system cancer.