It was shown that application of Reelin in older mice or in a model of a neurodevelopmental disorder improves synaptic function (↑ dendrite spine density and LTP) (Rogers et al., 2011) or restores behavioral and morphological deficits (mossy fibers; MF) (Ibi et al., 2020) in the hippocampus. Here, RELN is linked to neurodevelopmental disorder.