The decrease in MF density corresponds with a Reelin deficit in the dentate gyrus of the hippocampus in an animal model of schizophrenia, and both behavioral abnormalities and MF deficits can be rescued by delivery of exogenous Reelin into the dentate gyrus of the hippocampus (Ibi et al., 2020), supporting a role of Reelin in the remodeling of MF during disease progression of neurodevelopmental disorders. The gene discussed is RELN; the disease is neurodevelopmental disorder.