The increase of inulin-induced commensal Parabacteroides distasonis can increase the production of pentadecanoic acid, restore gut barrier integrity, and suppress hepatic steatosis and inflammation by decreasing serum levels of LPS and hepatic pro-inflammatory cytokines (eg, TNF-α and IL-6) in mouse NASH models [56]. The gene discussed is IL6; the disease is Hepatic steatosis.