SLC39A8 and hereditary hemochromatosis: As Zip8 expression has been shown to be upregulated in cell iron overload in the retina, and knock down of Zip14 is able to prevent iron overload in hepatocytes in a mouse model of hereditary hemochromatosis (408), elucidating ZIP8 and ZIP14 expression patterns (1) in the developing brain, and (2) after hemorrhage represent potential next steps toward understanding ZIP8 and ZIP14 as potential therapeutic targets to prevent brain iron overload after neonatal IVH.