Among the four genes, UCP2, UCP3, and CPT2 played a crucial role in fatty acid oxidation, it has proven that the downregulation of UCP2 and UCP3 impaired myocardial fatty acid oxidation and elevates the production of reactive oxygen species (ROS), subsequently increasing the incidence of arrhythmia [24,25]. Here, UCP3 is linked to Arrhythmia.