AGT and ACE protein and mRNA levels were elevated, whereas ACE2 activity and expression were decreased [145-149]. AKI decreases ANG1-7, ACE2, and MasR expressions, which increases free radicals, OS, creatinine, nitric oxide, and malondialdehyde (MDA) levels (Figure 2) [138]. The gene discussed is ACE2; the disease is acute kidney injury.