The calcium-permeable cation channel Amo, homologous to human PKD2, which is causative of Autosomal Dominant Polycystic Kidney Disease (ADPKD), has previously been shown to maintain calcium homeostasis downstream of Simu during later stages of efferocytosis in Drosophila (37). This evidence concerns the gene PKD2 and autosomal dominant polycystic kidney disease.