Several studies have shown that during osteoarthritis and cartilage degeneration, a significant elevation of CX3CL1 promotes the chemotactic recruitment of osteoclast precursor cells to the site of injury, whereas its chemotactic activity can be significantly inhibited by the use of CX3CL1-neutralizing antibodies (83–85). The gene discussed is CX3CL1; the disease is osteoarthritis.