In addition, accumulating evidences suggest that oncolytic VACVs induce immunogenic cell death (ICD) in infected cancer cells with the release of damage-associated molecular pattern molecules (DAMPs), such as the “danger” signals high mobility group box 1 (HMGB1), the “find me” signal adenosine triphosphate (ATP) and the “eat me” signal calreticulin (CRT) (29). The gene discussed is CALR; the disease is cancer.