Additionally, the polyphenol (especially anthocyanins)-rich extract of a berry originating from the Chilean Patagonia, maqui, actively downregulates proinflammatory proteins, shifts macrophage polarization towards resolution and activates the Nrf-2/HO-1 antioxidant response in a TNBS-induced model of CD-like colitis, suggesting the therapeutic potential of using natural polyphenols as a pharmaceutical intervention for IBD (28). This evidence concerns the gene HMOX1 and Cowden disease.