In summary, through WGCNA analysis and LASSO regression analysis, this study provides a better understanding of the role of biomarkers LINC01268, NME8, DMXL2, CXXC5, SCD, and FBN1, and provides a biological basis for further investigation of CML diagnosis and treatment. Here, FBN1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.