Based on the DEGs between CML and normal samples and the CML-related genes identified by WGCNA analysis, we used LASSO regression analysis to screen out 6 hub genes (LINC01268, NME8, DMXL2, CXXC5, SCD, and FBN1). This evidence concerns the gene CXXC5 and chronic myelogenous leukemia, BCR-ABL1 positive.