ROC curve analysis showed that all 6 hub gens had high AUC values for the diagnosis of CML, among which LINC01268 was 0.864 (95%CI: 0.796-0.924), NME8 was 0.869 (95%CI: 0.808-0.924), DMXL2 was 0.866 (95%CI: 0.805-0.91), CXXC5 was 0.831 (95%CI: 0.761-0.895), SCD was 0.856 (95%CI: 0.790-0.919), and FBN1 was 0.836 (95%CI: 0.767-0.900) (Figure 4A). This evidence concerns the gene CXXC5 and chronic myelogenous leukemia, BCR-ABL1 positive.