The DNA derived from apoptotic HCC cells stimulated the cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS)/stimulator of interferon genes (STING) signaling cascade in CD103+ DCs and triggered type I IFN (IFN-I) production, which eventually augmented the antitumor function of CD8+ T and NK cells. The gene discussed is STING1; the disease is hepatocellular carcinoma.