During tumor growth, although IL-13 levels substantially dropped to a very low level, and IL-25 remained very low, IL-4, IL-5, and IL-33 levels significantly increased, with a peak observed only on day 10 for IL-5, suggesting that IL-4, IL-5, and IL-33 related pathways may be activated along bladder tumor growth. The gene discussed is IL25; the disease is urinary bladder neoplasm.