PPARGC1A and acute kidney injury: PGC1α is suppressed in AKI (Portilla et al., 2002; Tran et al., 2011) and its suppression or deficiency worsens the renal injury, while its induction in renal tubular cells ameliorates ischemic AKI (Tran et al., 2011; Ruiz-Andres et al., 2016; Tran et al., 2016; Fontecha-Barriuso et al., 2019).