A novel series of coumarin-sulfamate hybrids was prepared as potential STS inhibitors.178 The inhibitory effects of the synthesized compounds were tested on STS isolated from the human placenta and against estrogen receptor-(ER)-positive MCF-7 and T47D cells, as well as ER-negative MDA-MB-231 and SkBr3 cancer cell lines. Here, ESR1 is linked to cancer.