Many studies in humans and rodents, demonstrate that MuRF1 gene (TRIM63) and protein expression increase following numerous atrophy models including disuse, denervation, cancer, renal failure, heart failure, burn injury, fasting, diabetes, corticosteroid treatment and cytokine exposure [[1], [2], [3], [4], [5], [6], [7]] Importantly, suppression of MuRF1 expression perturbs atrophy induced by denervation, glucocorticoid treatment, limb unloading, and lung injury [2,[8], [9], [10]]. The gene discussed is TRIM63; the disease is Renal insufficiency.