PLOD1 and Ovarian cyst: Consistent with our previous results [27, 28], the daily administration of the dose of 1 mg/kg of letrozole for 21 consecutive days induced a PCOS rat model possessing similar metabolic (overweight and dyslipidemia) and reproductive (hyperandrogenism, high LH levels, ovarian cysts, and infertility) disorders as seen in PCOS women.