By orchestrating the formation of a super multimolecular chaperone complex, HSP90 stabilizes the conformation of client proteins, interrupting their degradation and activating crucial pathways such as PI3K/Akt/mTOR and mitogen‐acivated protein kinase (MAPK), which are pivotal in regulating tumor cell proliferation and survival. This evidence concerns the gene HSP90AB1 and neoplasm.