Meanwhile, janus kinase (JAK2) and tyrosine kinase 2 (TYK2) possess the capability to induce the phosphorylation and activation of signl transducerand activator of transcription 1 (STAT1 )and STAT3, with the JAK2/tyrosine kinase 2 (TYK2)/STAT‐1/3 signaling axis being closely associated with tumor promotion.130, 131. This evidence concerns the gene STAT1 and neoplasm.