A key focus of the discussion will be to bring to the fore the weakness of the long-maintained dogma of “the human brain vulnerability to aging” (Ferrer, 2023), given the documented development of AD, PD, and TDP-43 pathology found in urban children residing in highly polluted environments (Calderón-Garcidueñas et al., 2018). The gene discussed is TARDBP; the disease is Alzheimer disease.