This study expands the MMC young residents’ development and progression of aberrant protein pathology, including Alzheimer’s disease, Parkinson’s disease, and the spectrum of dysregulation of the 43kD transactive response DNA/RNA-binding protein (TDP-43), the unifying hallmark of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Here, TARDBP is linked to Parkinson disease.