TF and neoplasm: Notably, some studies addressed the role of TF specifically in primary liver cancer: i) TF expression was correlated with tumor angiogenesis in HCC tissue samples, while increased TF levels were associated with decreased survival [53]; ii) TF expression was an independent risk factor of recurrence in patients undergoing surgery of curative hepatectomy for HCC [54]; and iii) TF levels were higher in both plasma and neoplastic tissues of patients with HCC and were associated with the index of invasion and metastasis [55].