F10 and thrombophilia: Regarding coagulation biomarkers, in earlier works in cardiovascular cohorts, we showed that high FVIIa-AT were associated with increased FXa and thrombin generation, thereby suggesting FVIIa-AT as an indicator of hypercoagulability [24,25] and, noteworthy, both FXa and thrombin generation have been related with a worse prognosis in cancer [60,61].