The association remained stable after further adjustments in Model II (sex, age, weight, smoking status, drinking status, and marital status; OR, 1.04 [1.01–1.07], P=0.022) and Model III (Model I + TBIL, ALB, ALT, AST, ALP, CREA, UA, TG, LDL, HDL, urea, ischemic cerebrovascular disease, CHD, hypertension, and DM; OR, 1.06 [1.01–1.12], P=0.012), the relationship between GGT and advanced colorectal adenoma remained stable. The gene discussed is GPT; the disease is diabetes mellitus.