Within muscle-invasive cancers, the TROP2/EpCAM ratio marginally changed from pT2 (3.7 ± 2) to pT3 (3.8 ± 1.9) and pT4 (3.9 ± 1.9) cancers, but these differences did not reach statistical significance (p=0.3). The gene discussed is TACSTD2; the disease is cancer.