Lysosomal transport regulatory factor (LYST) is a highly conserved homologous protein in mammals, which is classified as a member of the Beige and Chediak-Higashi syndrome (BEACH) family due to a special BEACH region (Burgess et al., 2009; Cullinane et al., 2013). The gene discussed is LYST; the disease is Chediak-Higashi syndrome.