TGFB1 and Myocardial fibrosis: We examined the expression of TGF-β in the myocardium of each group and found that Pue decreased the expression of TGF-β in ADR-induced myocardium, suggesting that the effect of Pue in reducing myocardial fibrosis may be related to the inhibition of TGF-β expression in myocardial tissue.