Our results suggest that Pue may exert myocardial protective effects by inhibiting the activation of p38MAPK and its downstream NHE1 activation, inhibiting myocardial fibrosis and the production of proinflammatory cytokines, attenuating mitochondrial damage caused by calcium overload, and improving myocardial contractile function. This evidence concerns the gene SLC9A1 and Myocardial fibrosis.