CD8A and dementia: CD8 was significantly higher in HAD compared to non‐dementia patients in the BG and parietal regions (p < 0.05).CD68 was significantly higher between HAD and NCN the difference was observed in BG, parietal and MB (p < 0.05).S‐100A8 immunohistochemical staining was also pronounced in the deeper midline and mesial temporal structure in HAD brains.