We observed directionally concordant associations with MS in both the discovery and replication cohorts for 28/34 (82.4%) proteins, including most of the proteins increased in MS in UKB (IL17RB, NEFL, CTSF, MERTK, GFAP, LILRB4, and LAMP3), but not IL15. This evidence concerns the gene LILRB4 and myeloid sarcoma.