In addition to the established markers of neuroaxonal damage NFL and GFAP, we identify elevation of several plasma proteins in MS patients, including cytokines and cytokine receptors (IL22, IL17RB, and IL15), proteins involved in lysosomal processing (LAMP3, CTSF), and regulators of monocyte/microglial function (MERTK, LILRB4).12, 32, 33, 34, 35, 36. This evidence concerns the gene NEFL and myeloid sarcoma.