MUC5AC and chronic rhinosinusitis with nasal polyps: IL‐6 is a multifunctional B‐cell differentiation factor that can promote Th2 cell differentiation and is produced by various types of cells, such as T cells, B cells, monocytes, etc.80IL‐6 can induce the pathologic and physiological process of CRSwNP,81 regulate the expression of IL‐13 in human lung epithelial cells, thus inducing airway mucous cell metaplasia, or directly induce the expression of Muc5ac and Muc5b genes in vitro.82, 83