KLRK1 and colitis: The NKG2D-NKG2DLs axis is involved in the development of autoimmune and inflammatory diseases (rheumatoid arthritis, colitis, celiac disease, and autoimmune diabetes) through induction of activation of the NF-κB signaling pathway18–20.To data, there are few reports to describe the expression of NKG2D in the central nervous system (CNS) and the potential role of the NKG2D-NKG2DLs axis in neonatal HIBD.