NUAK1 and plasma cell myeloma: This study demonstrated that ARK5 enhanced cell growth and migration of MM cells that was shown in the application of human myeloma isogenic cell clones with or without ARK5. ARK5 knockout causes the rightward shift from fission to fusion, indicating that MM cells have elevated mitochondrial fission, which represent the association of ARK5 with mitochondrial morphological dynamics in MM cells.