In this study, we further identified novel target genes for miR-361-3p, ETV7 and BATF2, and demonstrated through in vivo and in vitro experiments that exosomal miR-361-3p can activate the PAI-1/ERK pathway by inhibiting ETV7 and BATF2, thereby enhancing the vitality of BC cells. This evidence concerns the gene SERPINE1 and breast cancer.