Mutations associated with detrimental biological behavior were more abundant in the high-risk group than in the low-risk group, such as TP53 (36% vs. 24%), a well-known anti-oncogene that is one of the most frequently mutated genes in HCC specimens, and DOCK2 (9% vs. 3%), a mediator of cytokinesis21. This evidence concerns the gene DOCK2 and hepatocellular carcinoma.