After removing rs4841132 associated with fasting blood glucose and insulin, rs7896518 associated with BMI, rs6511720 associated with low-density lipoprotein and CAD, rs8176645 associated with lipids profile, 62 SNPs for mtDNA copy number were contained in the association between mtDNA copy number and cardiometabolic disease (Additional file 1: Table S1). Here, INS is linked to coronary artery disorder.