Persistent hypoglycemia due to pituitary hormone deficiency, adrenal insufficiency, growth hormone deficiency and dysregulated insulin secretion by the pancreatic β-cells57,58 are also more frequent in KS210, possibly because the inhibition of KDM6A increases the release of insulin from pancreatic islet cells, as suggested by mouse models1,59. Here, INS is linked to hypopituitarism.