GJB2 and deafness: Importantly, the proband of Family P34 had deafness and CVD, HEDEP indicated that he had a homozygous deletion variant (p. Leu79Cysfs*3) in GJB2 gene, which has been reported to cause AR deafness(Lin et al. 2022; Xia et al. 2019), while no CNV in GJB2 gene was detected by QF-PCR.