For example, the SNPs rs7412 and rs429358 in exon IV of the apolipoprotein E gene generate the APOE4 variant, which is associated with elevated levels of circulating and tissue cholesterol, oxidized low-density lipoprotein (LDL), and increased risk for late-onset Alzheimer's disease (reviewed previously in [15]). This evidence concerns the gene APOE and Alzheimer disease.