STAT3 and glioblastoma: Liang et al. [201] also prepared exosomes loaded with angiopep-2 (An2)-functionalized signal transducers and activators of transcription 3 (STAT3)-siRNA to target GBM cells and BBB endothelial cells through An2 binding to low-density lipoprotein receptor-related protein 1 (LRP-1), to promote Exo-An2-siRNA penetration into the BBB and target GBM.