M1 macrophage-derived exosomes are modified with aCD47 and aSIRPα on their membrane surface by click chemistry, which can specifically recognize CD47 on the membrane surface of tumor cells and SIRPα on the membrane surface of macrophages in vivo, thus blocking the "don't eat me" signaling between tumor cells and macrophages and allowing the active targeting of tumors. This evidence concerns the gene SIRPA and neoplasm.