TNF and myocardial infarction: However, consistent with our observations in the primary macrophages (Fig. 3A), CoQ10 treatment significantly downregulated the gene transcripts of Il1β, Tnfα, and Ccl2, whereas no difference in Il6, Nlrp3, or iNOS was observed between vehicle and CoQ10-treated MI mice at 3 days after LAD ligation (Fig. 4A, Supplemental Fig. 8).