The infarct myocardium of post-LAD ligation in vehicle-treated MI mice displayed significantly upregulated mRNA expression of Il1β, Il6, Tnfα, Nlrp3, Caspase1, Il18, iNOS, and Ccl2 compared with sham mice, indicating the enhanced inflammation in the infarct area induced by LAD ligation. This evidence concerns the gene IL18 and myocardial infarction.