When compared to the infarcted myocardium of vehicle-treated MI mice at 28 days after LAD ligation, similar results were observed: CoQ10 treatment effectively reduced the gene transcripts of pro-inflammatory cytokines (including Il6, Tnfα, Nlrp3, and Caspase1) in the CoQ10-treated MI mice (Supplemental Fig. 9). The gene discussed is NLRP3; the disease is myocardial infarction.