IDH2 and intrahepatic cholangiocarcinoma: Similarly, Eluri et al. also observed that MSI-H cases had lower frequencies of previously identified, actionable ICC drivers, such as FGFR2 fusions (0% vs. 9%, p = NS), IDH1 (3.7% vs. 14.5%, p < 0.0001), and IDH2 (0% vs. 4.1%, p = 0.007) [50].