Eleven potential prognostic variables for OS were selected based on univariate Cox analysis, including age, largest tumor size, ECOG PS, treatment line, combination agents, PD-L1 (CPS ≥ 1), PD-L1 (CPS ≥ 5), MSI status, TMB (≥ 10 muts/Mb), SWI/SNF pathway, and MMR pathway (Table 1). The gene discussed is MRC1; the disease is neoplasm.