Several mechanisms have been proposed to explain the cognitive decline occurring in older adults with low BP values, including the harmful effects of cerebral hypoperfusion that could lead to oxidative stress, synaptic dysfunction, tau hyperphosphorylation, beta amyloid accumulation, and neuroinflammation [18–20] or the possibility of a “reverse causation” scenario, whereby the onset of dementia itself may impact the central control of BP [21]. The gene discussed is MAPT; the disease is dementia.